妊娠高血压综合征患者血清及尿β_2—微球蛋白测定的意义

研究目的探讨β_2—微球蛋白与妊娠高血压综合征临床意义研究设计病例对照研究研究对象 36例妊娠高血压综合征患者,孕周28～40周,年龄22～30岁;对照组为40例正常晚期妊娠孕妇。处理方法妊娠高血压综合征患者及正常孕妇血清和尿,用放射免疫分析法测定β_2—微球蛋白水平。同时测血尿素氮(BUN)以对照,测定结果进行t检验。测定结果 36例妊娠高血压综合征患者及40例正常晚期妊娠孕妇血清β_2—微球蛋白测定值分别为4.98±1.50mg/L和2.57±1.43mg/L(p<0.01,t检验)。29例妊娠高血压综合征患者及23例正常孕妇尿β_2—微球蛋白水平分别为1.03±0.91mg/L和0.55±0.40mg/L(P<0.05)。33例妊娠高血压综合征患者及25例正常孕妇,血尿素氮(BUN)测定值分别为6.16±4.17mmol/L和6.173±3.84mmol/L(P>0.05)。结论妊娠高血压综合征患者血清及尿β_2—微球蛋白水平均明显高于正常晚期妊娠孕妇,血清及尿β_2—微球蛋白测定是监测妊娠高血压综合征患者肾功能受损较敏感的方法。

THE SIGNIFICANCE OF THE DETERMINATION OF 尾_2-MICROGLOBULIN IN SERUM AND URINE IN PATIENTS WITH EDEMA-PROTEINURIA- HYPERTENSION SYNDROME

Objetive To search for the clinical significance of β_2—microgliobulin (β_2—M) and edema-proteinuria-hypertension syndrome (EPH syndrome). Design Case—control research. Patients and Other Participants Thirty—six cases with EPH syndrome. The range of pregnancy is 28～40 weeks. The range of age is 22～30 years old. There are 40 normal women with late pregnancy in the control group. Interventions The levels of β_2-M of serum and urine were determined by radioimmunoassay in the patients with EPH syndrome and normal late pregnancy, in the mean time, we determine BUN to contrast.The t—test of measurement was made. Results The β_2—M values from 36 cases and 40 mormal late pregnancy are 4.98±1.50mg/L and 2.57±1.43mg/L respectively.The β_2—M levels from 29 cases and 23 normal pregnancy are 1.03±0.91mg/L and 0.55± 0.40mg/L respectively.The BUN values of 33 cases, and 25 normal pregnancy are 6.16±4.17mmol/L and 6.173±3.84mmol/L (P>0.05) respectively. Conclusion The level of β_2-M of serum and urine in patients with EPH syndrome is significantly higher than that in normal late pregnancy. Determination of β_2—M of serum and urine is a sensitive method of judging kindney function in patients with EPH syndrome.