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Influence of perinatal inflammation on the neurodevelopmental outcome of premature infants |
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| Authors: | Adriano Rodríguez-Trujillo José Ríos Martina A. Ángeles David E. Posadas Clara Murillo Claudia Rueda |
| Affiliation: | 1. BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Fetal i?+?D Fetal Medicine Research Center, IDIBAPS, University of Barcelona, Barcelona, Spain;2. Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic, Barcelona, Spain;3. Biostatistics Unit, Faculty of Medicine, Universitat Autónoma de Barcelona, Barcelona, Spain |
| Abstract: | Objective: To evaluate the influence of perinatal inflammation on neurodevelopmental outcome of premature infants. Study design: From a retrospective cohort study of women with preterm labor with intact membranes or preterm prelabor rupture of membranes (PPROM) with an amniocentesis to rule out intra-amniotic inflammation (IAI) and microbial invasion of the amniotic cavity (MIAC), we evaluated neurodevelopmental outcome of their infants born between 24.0 and 34.0 weeks gestation. Women with clinical chorioamnionitis at admission were excluded. Neurodevelopmental outcome was screened with the Ages & Stages Questionnaire (ASQ)-3. We analyzed the relationship between an altered ASQ-3 and antenatal, intra-partum and post-partum factors related to perinatal inflammation. Result: Among 98 infants evaluated, 22% had an abnormal score. Amniotic fluid interleukin-6 levels and early-onset sepsis (EOS) were independent factors of an altered ASQ-3 with delivery <26.0 weeks being the strongest predictor. Conclusions: In premature infants, the presence of IAI, delivery <26.0 weeks and EOS were found to be independent factors of an altered ASQ-3. |
| Keywords: | Infants outcomes women |