高频条件不同机械指数下SonoVue与Sonazoid对兔肝超声造影效能的比较

目的 比较高频条件下SonoVue与Sonazoid在不同机械指数(MI)下对兔肝超声造影的效果.方法 在高频(7 MHz)条件下,分别对8只新西兰大白兔多次团注SonoVue(0.06 mL/kg)及Sonazoid(0.045 mL/kg)进行超声造影.SonoVue组分别设置7个MI值(0.10、0.15、0.25、0.30、0.40、0.50、0.55),Sonazoid组分别设置5个MI值(0.19、0.40、0.62、0.78、0.98).应用时间-强度曲线(TIC)进行定量分析,并分析兔肝超声造影增强效果及灌注参数与MI值的相关性.结果 在相同发射频率(7 MHz)条件下,SonoVue组随着MI值逐渐升高,峰值强度(PI)呈上升趋势,于MI=0.15时达最大值;同时,当MI≤0.25时,其TIC上升时间(RT)、达峰时间(TTP)较为稳定(P＞0.05);之后随着MI值的增大,RT、TTP呈下降趋势(P＜0.01).Sonazoid组随着MI值逐渐升高,PI呈上升趋势,于MI=0.40时达最大值;同时,随着MI值的逐渐升高,其RT、TTP未见明显变化(P＞0.05).结论 SonoVue与Sonazoid理化特性不同,高频(7 MHz)条件不同MI下其肝脏超声造影效能各不相同.

The imaging effect on rabbit's liver by SonoVue and Sonazoid in the high-frequency state with different mechanical indices

Objective The contrast enhancement of SonoVue and Sonazoid were compared in rabbit s liver with ultrasound frequency of7 MHz usinga rangingmechanical index(MI).Methods In the high frequency state (7 MHz),a total of 8 rabbits (weight 2.30±0.30 kg) were bolus injected with two contrast agents:Once the SonoVue (0.06 mL/kg) was injected,the MI was observed ranging from0.10 to0.55 (0.10,0.15,0.25,0.30,0.40,0.50,0.55);after injection of Sonazoid (0.045 mL/kg),MI was found ranging from 0.19 to 0.98 (0.19,0.40,0.62...