原发性开角型青光眼视网膜神经纤维层厚度和视野平均缺损的相关性分析

目的 比较原发性开角型青光眼患者GDx VCC各参数和自动视野平均缺损(MD)的相关性.方法 用GDx VCC和Octopus1-2-3自动视野检测97例(191眼)原发性开角型青光眼患者.采用方差分析、Pearson相关分析和回归分析GDx各参数和自动视野平均缺损(mean defect,MD)之间的关系.结果 GDx各参数与视野的MD均呈负相关,相关性依次为:SA(-0.58)、TSNIT(-0.52)、IA(-0.52)、NFI(-0.48)和IES(-0.33),差异有统计学意义.上半野视野与GDx下象限RNFL厚度参数一致性为-0.61,下半野视野与GDx上象限RNFL厚度参数的一致性为-0.59.结论 GDx参数和自动视野的平均缺损呈中度相关.GDx可用于青光眼的随诊.

Abstract：

Objective To establish whether the structural parameters provided by GDx can be used to reflect functional damage in the mean defect of visual field. Methods 97 ( 191 eyes) patients with primary open angle glaucoma underwent examination with GDx and Octopus 1-2-3 automatic perimeter. The relationship between the retinal nerve fiber layer parameters and mean defect of visual field was analysed by ANOVA, Pearson's correlation (r), scatter plot and linear regression. Results The parameters of GDx decreased with increasing mean defect of visual field, measured both globally and regionally; r: SA=- 0.58, TSNIT =-0.52, IA=-0.52, NFI=-0.48 and IES=-0.33. All parameters were negative correlation with mean defect of visual field and there was significant correlation among these parameters,except IES(P＜0.05). The superior mean defect of visual field increased with decreasing inferior RNFL (r=-0.61), inferior visual field mean defect increased with decreasing superior RNFL (r=-0.59).There were significant correlation among these parameters. Conclusion Quantitative measures of the retinal nerve fiber layer using GDx were correlated with mean defect of visual field in patients with glaucoma. GDx can be used for follow up.

Correlation between quantitative nerve fiber layer thickness and mean defect of visual field in primary open angle glaucoma

Objective To establish whether the structural parameters provided by GDx can be used to reflect functional damage in the mean defect of visual field. Methods 97 ( 191 eyes) patients with primary open angle glaucoma underwent examination with GDx and Octopus 1-2-3 automatic perimeter. The relationship between the retinal nerve fiber layer parameters and mean defect of visual field was analysed by ANOVA, Pearson's correlation (r), scatter plot and linear regression. Results The parameters of GDx decreased with increasing mean defect of visual field, measured both globally and regionally; r: SA=- 0.58, TSNIT =-0.52, IA=-0.52, NFI=-0.48 and IES=-0.33. All parameters were negative correlation with mean defect of visual field and there was significant correlation among these parameters,except IES(P＜0.05). The superior mean defect of visual field increased with decreasing inferior RNFL (r=-0.61), inferior visual field mean defect increased with decreasing superior RNFL (r=-0.59).There were significant correlation among these parameters. Conclusion Quantitative measures of the retinal nerve fiber layer using GDx were correlated with mean defect of visual field in patients with glaucoma. GDx can be used for follow up.