芹菜对小鼠生育力及胎鼠生长发育的影响

目的探讨芹菜对雄性小鼠生殖能力及胎鼠生长发育的影响。方法160只成年健康SPF级昆明种雄性小鼠按体质量随机分为7d和56d两个时间组，各时间组随机分为对照组、低剂量组、中剂量组、高剂量组，每天定时给各剂量组小鼠以不同浓度的芹菜汁0．3ml灌胃，对照组0．3ml生理盐水灌胃，灌胃结束后与同种同龄的健康雌性小鼠按雄雌1：1合笼；次日起每日阴道涂片，以查到阴栓为孕0d（合笼7d未见阴栓者，以合笼第4天为孕0d），并分笼饲养，分别在孕18d剖腹取胎，记录各组孕鼠受孕及子宫仔鼠着床情况，同时测定胎鼠身长及体质量。结果各剂量组与对照组比较雌鼠受孕率、着床数、胎鼠身长、体质量差异均无统计学意义。结论芹菜对胎鼠生长发育无明显影响，对雄鼠生育力的影响不能排除。

Effect of celery on fertility of mice and growth and development of fetus

Objective To explore the effect of celery on the reproductive capacity of male mice and the growth and development of fetus. Methods 160 healthy aduh male SPF mice of Kunming strain were divided randomly into 7 days and 56 days time groups. Each group was divided into 4 groups including control group,low-dose group, middle-close group and high-dose group according to the body weight. Mice of each group were administered by gavage at a certain time every day, control group with 0. 3 mililiters of normal saline and experimental groups with 0. 3 mililiters of celery juice of different concentration. After intragastric administration, male mice were mated 1：1 with untreated females for 7 days （time for completion of one estrous cycle in mice）. The daily vaginal smears were checked. The day that vaginal plug was found was considered day 0 of gestation, and then the male and female mice were separated into different cages. The fetal mice were obtained by caesarean on day 18 of gestation. The pregnant rate,embryonic nidation of each group and the length and weight of fetus were recorded. Results There were not statistical significances in pregnant rate of female mice, number of embryonic nidation, or length and weight of fetus among any group（P 〉0. 05）. Conclusion Celery had no significant effect on growth and develop- ment of fetal mice, but the effect on reproductive capacity of male mice can not be excluded.