哈尔滨市妇女宫颈病变人乳头状瘤病毒的感染状况及基因亚型分析

目的 了解哈尔滨市妇女宫颈病变人乳头瘤病毒(human papillomavirus,HPV)感染率和亚型分布.方法 于2009年9月至2010年11月,对就诊于哈尔滨医科大学附属第二医院妇产科的1 029例哈市妇女进行HPV DNA分型检测,得出HPV感染亚型.结果 1 029例妇女中,HPV感染患者为321例,总感染率31.20％ (321/1 029),其中高危型HPV、低危型HPV、及HPV复合感染率分别为25.66％ (264/1 029)、5.54％ (57/1 029)、7.09％ (73/1 029)；HPV感染的亚型中,HPV16(9.72％,100/1029)最常见,其次为HPV53 (4.08％,42/1 029).结论 调查人群中宫颈病变患者HPV感染有一定的区域性,HPV16、HPV53可能是哈尔滨市妇女较易感染的亚型,值得重视.

Prevalence of human papillomavirus infection among women with cervical lesion in Harbin

Objective To investigate human papillomavirus(HPV) prevalence and subtypes distribution among women with cervical lesion in Harbin.Methods During September 2009 to November 2010,the HPV types were tested among 1 029 women who were suspected to be suffering from HPV infection or cervical lesion in Harbin.Results The overall positive rate of involved 1 029 women was 31.20%(321/1 029),of which 25.66%(264/1 029) were infected by high-risk types,5.54%(57/1 029) by low-risk types,and 7.09%(73/1 029)by multiple infection.Twenty-one types were detected,of which HPV16(9.72%) was the most common type,followed by HPV53(4.08%).Conclusion Cervical HPV infection has certain regionity.HPV16 and HPV53 is the common type in the HPV infection of suspected to be suffering from HPV infection or cervix lesion in Harbin.