249例海洛因依赖者感染HBV和HCV及肝功能分析

目的：调查分析郴州市海洛因依赖者中感染乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）及肝功能状况，了解吸毒人群经血传播疾病的危险因素，为这组人群的疾病预防控制提供科学依据。方法：用酶联免疫吸附试验（ELISA）分别检测249例海洛因依赖者的血清标志物即：HBsAg、抗-HCV，同时用全自动生化分析仪检测丙氨酸氨基转移酶（ALT）。结果：249例海洛因依赖者的HBsAg阳性率为18．88％、抗-HCV阳性率为73．9％、ALT异常率为37．8％。IDU组与nIDU组进行比较抗-HCV阳性率、ALT异常率差异有显著意义或极显著意义。结论：吸毒是HBV、HCV感染的高危险因素，静脉吸毒更是导致HCV高感染率的最主要因素，同时会导致肝功能异常。

Analysis of HBV, HCV infection and liver function in 249 cases of heroin addicts

Objective： To investigate hepatitis B virus （HBV）, hepatitis C virus （HCV） infection and liver function among heroin addicts in Chenzhou, and find out the risk factors that the diseases were transmitted by blood route ,so that provide scientific basis for disease prevention and control among this population. Methods： HBsAg, anti - HCV, the serum markers of 249 heroin addicts were detected with enzyme-linked immunosorbent assay （ELISA）,and ALT was detected by automatic biochemical analyzer. Results： In 249 cases of heroin addicts,HB- sAg-positive rate was 18.88%, anti - HCV-positive rate was 73.9% and ALT abnormal rate was 37.8%. There were significant differences in anti - HCV-positive rate and ALT abnormal rate between IDU group and nIDU group. Conclusion： Drug abuse is a high-risk factor of HBV, HCV infection. Intravenous drug use is the most important factor leading to a high HCV infection rate and abnormal liver function.