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Long-term interleukin-2 assessment after conversion from a twice-daily to once-daily tacrolimus regimen in stable kidney recipients |
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| Authors: | I Umbro F Tinti A Mecule A Bachetoni L Poli A Pignatelli C Alessandri F Fiacco M D'Alessandro V Di Natale P B Berloco G Valesini A P Mitterhofer |
| Affiliation: | a Department of Clinical Medicine, Nephrology and Dialysis Unit, 1st Faculty of Medicine and Surgery, Sapienza University of Rome, Rome, Italy b Department of General Surgery, Organ Transplant Unit “Paride Stefanini”, 1st Faculty of Medicine and Surgery, Sapienza University of Rome, Rome, Italy c National Institute of Geophysics and Vulcanology Rome, Rome, Italy d Department of Internal Medicine and Clinical Specialities, Rheumatological Unit, Sapienza University of Rome, Rome, Italy |
| Abstract: | Conversion to tacrolimus (Tac) to once daily (Tac-O) formulation is commonly followed by a 20% reduction in Tac trough levels in the first month. It is not associated with modifications of renal function but there is the issue of its effects on inflammatory cytokines and on subclinical rejection. The aim of our study was to evaluate long-term interleukins (IL)-2 profiles in stable renal transplant patients after Tac-O conversion. We enrolled 10 stable kidney transplant patients converted to Tac-O. Tac trough levels, serum creatinine concentrations, glomerular filtration rate using the Modification of Diet in Renal Disease formula, C-reactive protein, IL-2 levels, and clinical assessments were performed monthly for 6 months before and 12 months after conversion. Despite the significant reduction in Tac trough levels, we did not observe alterations suggestive of clinical or subclinical acute rejection. |
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