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No association of DPP6 with amyotrophic lateral sclerosis in an Italian population |
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| Authors: | Isabella Fogh,Sandra D&rsquo AlfonsoCinzia Gellera,Antonia RattiCristina Cereda,Silvana PencoLucia Corrado,Gianni Sorarù Barbara Castellotti,Cinzia TilocaStella Gagliardi,Lorena CozziMichelle K. Lupton,Nicola TicozziLetizia Mazzini,Chris E. ShawAmmar Al-Chalabi,John PowellVincenzo Silani |
| Affiliation: | a MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK b Dept. of Medical Sciences, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy c Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy d Dept. of Neurology and Lab. Neuroscience, “Dini Ferrari” Center, University of Milan Medical School-IRCCS Istituto Auxologico Italiano, Milan, Italy e IRCCS Institute of Neurology C. Mondino, Pavia, Italy f Hospital Niguarda Ca’Granda, Milan, Italy g University of Padua, Italy |
| Abstract: | We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P = 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts. |
| Keywords: | Amyotrophic lateral sclerosis Genome-wide association study Polymorphism Dipeptidyl-peptidase 6 (DPP6) gene |
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