元宝草的化学成分研究

目的：对元宝草的化学成分进行研究。方法：利用硅胶、聚酰胺、Sephadex LH-20和大孔树脂柱层析对化合物进行分离，并利用光谱技术和理化性质进行结构鉴定。结果：从元宝草乙醇提取液的二氯甲烷萃取物中分离得到5个化合物，鉴定为二十八烷醇（octacosanol，化合物1）、三十烷酸（triacontanoic acid，化合物2）、豆甾醇（stigmasterol，化合物3）、苯甲酸（benzoic acid，化合物4）和1-羟基-7-甲氧基咕吨酮（1-hydroxy-7-methoxy-xanthone，化合物5）；从乙酸乙酯萃取物中分离得到3个化合物，鉴定为没食子酸（3，4，5-trihydroxy-benzoic acid，化合物6）、槲皮素（quercetin，化合物7）和1，3，6，7-四羟基咕吨酮（1，3，6，7-tetrahydroxy-xanthone，化合物8）。结论：除化合物7以外，其余7个化合物均为首次从元宝草中分离得到。

Study of the chemical constituents of Hypericum sampsonii

Objective: To study the chemical constituents of Hypericum sampsonii Hance.Methods: The compounds were isolated by column chromatography using silica gel,polyamide,Sephadex LH-20 and macroreticular resin,and the structures were elucidated by UV,IR,MS,~(1)H-NMR,()~(13)C-NMR spectral analysis and their physicochemical properties.Results: From the CH_(2)Cl_(2) fraction of the EtOH extract of crude drug,5 compounds were isolated and identified as octacosanol(compound 1),triacontanoic acid(compound 2),stigmasterol(compound 3),benzoic acid(compound 4) and 1-hydroxy-7-methoxy-xanthone(compound 5);and from EtOAc fraction of the EtOH extract 3 compounds were isolated and identified as 3,4,5-trihydroxy-benzoic acid(compound 6),quercetin(compound 7) and 1,3,6,7-tetrahydroxy-xanthone(compound 8). Conclusion::All these compounds are obtained from H.sampsonii for the first time except compound 7.