支气管哮喘蛋白质组学研究的现状和前景

蛋白质组学是后基因组时代一项重要的生命科学的研究手段，近年在支气管哮喘的发生、发展方面的研究方兴未艾。它主要依托质谱和二维电泳技术比较正常和病理状态下组织或细胞的差异蛋白质的表达，结合生物信息学的方法，从而研究疾病的发病机制及为临床提供诊断和治疗靶点。在哮喘的研究中目前主要是比较蛋白质组学的研究，发现新的靶标为临床服务同时探讨其发病机制。

The status quo and perspective of proteomic study in bronchial asthma

Proteomics is an important investigative method of life science in the post-geomic era,it just start to grow in the research on the development of bronchial asthma.Different proteins of normal and pathological tissues and cells are compared by mass spectrometry and two-dimensional electrophoresis which are combined with bioinformatics.Thereby,it is its main purpose to study the mechanism of the disease and to provide the diagnostic and therapeutic biomarker for clinical works.In the study of bronchial asthma,comparative proteomics as a kind of important method,is useol to find new biomarker for clinical works and discuss the mechanism of asthma.