雌二醇对大鼠动脉损伤后内膜增殖的影响

目的：探讨雌二醇对去势大鼠颈总动脉球囊损伤后内膜增殖的影响。方法：选择8～10wSD大鼠，分为雌、雄性组，各有3个亚组：非去势对照组、雌二醇试验组。腹腔注射雌二醇3d后，2．0mmPTCA球囊导管损伤左颈总动脉。动脉损伤后2w处死大鼠，图像处理仪测量内膜、图像处理仪测量内膜面积、内膜面积／肌层面积。结果：雄性试验组内膜面积、内膜面积／肌层面积，均显著比非去势对照组减小（均P＜0．01），比去势对照组减小（均＜0．05）；雌性试验组内膜组织、内膜／肌层均显著比去势对照组减小（P＜0．01），与非去势对照组差异不大（P均＞0．05）。结论：雌二醇对去势大鼠颈总动脉内膜球囊损伤后均具有抑制内膜增殖作用。

Effect of estradiol on inhibition of neointimal p roliferation in rats after the lnjury of carotid arteries

Objective　To investigate the effec t of estradiol on inhib ition of neointimal proliferation after carotid common arteries of rats we re injured with balloon catheter.Methods　Eight-ten weeks old SD rats were divided into groups male(n=21) and famale(n=21),in which consists of subgroups intact control,gonadectomized control,and estradiol.Left carotid common arteries were not injured with 2.0 FPTCA balloon catheter until estradiol had injected for t hree days.Then rats were killed in two weeks.Neointimal areas,ratios of intima/m edia in artery,were measured with computer.Results　Neointimal areas and ratios of intimate/media,in male,in subgroup estradiol were less than those in the intact control significan tly(all P＜0.01),and those in the gonadectomized control(all P＜0.05). Thos e,in female,in the estradiol were less than those in the gonadectompzed control evidently(all P＜0.01),were smilar to those in the intact control(all P＞0.05).Conclusions　Estradiol inhibits neointimal proliferation a f ter the gonadectomized rats carotid artery were injured with balloon catheter.