| 早期高血压主动脉单核细胞趋化因子-1的表达 |
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| 引用本文： | 谢启应,孙明,杨天(山仑),周宏研. 早期高血压主动脉单核细胞趋化因子-1的表达[J]. 中南大学学报(医学版), 2003, 28(2): 145-148 |
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| 作者姓名： | 谢启应 孙明 杨天(山仑) 周宏研 |
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| 作者单位： | 中南大学湘雅医院心内科,长沙,410078;中南大学湘雅医院心内科,长沙,410078;中南大学湘雅医院心内科,长沙,410078;中南大学湘雅医院心内科,长沙,410078 |
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| 摘 要： | 目的 :探讨高血压早期主动脉壁单核细胞趋化因子 1(MCP 1)的表达。方法 :用原位杂交和RT PCR方法检测急性期两肾一夹 ( 2K1C)高血压大鼠在血压升高不同时间主动脉壁MCP 1的表达。结果 :正常血压大鼠主动脉壁无MCP 1的表达 ;在 2K1C大鼠高血压形成一周 ,主动脉壁MCP 1即有表达 ,并随时间延长 ,其表达持续增加。结论 :提示高血压早期即有主动脉壁MCP 1的表达 ,并随时间延长增加 ,这可能与其加速动脉粥样硬化形成有关。
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| 关 键 词： | 单核细胞趋化因子-1 高血压 主动脉 |
| 文章编号： | 1000-5625(2003)02-0145-04 |
| 修稿时间： | 2002-06-11 |
Expression of monocyte chemoattractant protein-1 in aorta of early hypertensive rats |
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| XIE Qi-ying,SUN Ming,YANG Tian-lun,et al.. Expression of monocyte chemoattractant protein-1 in aorta of early hypertensive rats[J]. Journal of Central South University. Medical sciences, 2003, 28(2): 145-148 |
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| Authors: | XIE Qi-ying SUN Ming YANG Tian-lun et al. |
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| Affiliation: | (Department of Cardiology,Xiangya Hospital,Central South University,Changsha 410078, China) |
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| Abstract: | Objective To investigate the expression of monocyte chemoattractant protein-1(MCP-1) of aorta wall in acute phase of hypertension in rats with 2 kidney and 1 clip(2K1C).Method The MCP-1 mRNA on aorta wall was detected by in situ hybridization and reverse transcription-polymerase chain reaction(RT-PCR). Results No MCP-1 was expressed in normal rat, but it was expressed on the aorta wall of rats in 1 week after 2K1C hypertensive model was formed.The expression of MCP-1 increased with the development of hypertension.Conclusion The expression of MCP-1 on aorta wall of 2K1C hypertensive rats increases in the early stage of hypertension,which may play an important role in accelerating atherosclerosis. |
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| Keywords: | monocyte chemoattractant protein-1 hypertension aorta |
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