| 急性脑梗死并发脑心综合征大鼠心脏一氧化氮含量的变化及意义 |
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| 引用本文： | 吕在刚,杜业亮,焦迎晖. 急性脑梗死并发脑心综合征大鼠心脏一氧化氮含量的变化及意义[J]. 现代医药卫生, 2011, 27(5): 644-645 |
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| 作者姓名： | 吕在刚 杜业亮 焦迎晖 |
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| 作者单位： | 1. 潍坊医学院,山东,潍坊,261041
2. 潍坊市人民医院,山东,潍坊,261041 |
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| 摘 要： | 目的:研究脑心综合征(CCS)大鼠心脏一氧化氮(NO)含量的变化,为CCS发病机制提供理论依据.方法:试验大鼠被分为3组,CCS组(n=10);单纯脑梗死组(n=10);假手术对照组(n=10).采用线栓法栓塞大鼠右侧大脑中动脉,连续监测大鼠大脑中动脉栓塞后缺血2 h标准Ⅱ导联心电图后,取大鼠心脏检测NO含量.结果:在脑缺血后2h,CCS组较单纯脑梗死组大鼠心脏NO含量增高,P＜0.05;单纯脑梗死组与假手术对照组相比NO含量增高,P＜0.05;CCS组较假手术对照组心脏NO含量明显增高,P＜0.05,具有统计学意义.结论:急性脑梗死并发CCS的发生可能与心脏NO含量异常升高有关.
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| 关 键 词： | 一氧化氮 脑梗死 脑心综合征 心脏 大鼠 |
Changes of nitric oxide content in rat heart with cerebrocardiac syndrome following acute cerebral infarction |
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| LV Zai-gang , DU Ye-liang , JIAO Ying-hui. Changes of nitric oxide content in rat heart with cerebrocardiac syndrome following acute cerebral infarction[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2011, 27(5): 644-645 |
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| Authors: | LV Zai-gang DU Ye-liang JIAO Ying-hui |
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| Affiliation: | LV Zai-gang1,DU Ye-liang2,JIAO Ying-hui2(1.Weifang Medical College,Weifang,Shandong 261041,China,2.Weifang People's Hospital,China) |
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| Abstract: | Objective:To observe the changes of nitric oxide in the rats heart suffered from cerebrocardiac syndrome and to offer a theoretical basis for the pathogenesis of cerebrocardiac syndrome.Methods:Whistar rats were divided into three groups,the cerebrocardiac syndrome group(n=10),the only cerebral infarction group(n=10) and the sham operation group(n=10).Right middle cerebral artery of rat was occluded(MCAO) and II lead ECG was monitored continuously within 2 h to record the emerging of arrhythmias,and then ta... |
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| Keywords: | Nitric oxide Cerebral infarction Cerebral-cardiac syndrome Heart rat |
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