乙型肝炎病毒宫内感染对新生儿发育影响

目的评价乙型肝炎病毒携带孕妇新生儿体格发育状况，研究发生乙型肝炎病毒宫内感染对新生儿发育的影响。方法按标准方法测量新生儿的体重、身高、头围和胸围。214名新生儿中，将新生儿是否发生乙型肝炎病毒（HBV）宫内感染分为宫内感染组和未感染组，采用Z值法评价新生儿的发育状况。结果214名新生儿中有3例（1．40％）新生儿的胎龄别身长Z得分〈-2，为发育迟缓。宫内感染组和未感染组新生儿的体重Z得分（t=0．21，P：0．832）、身长Z得分（t=1．60，P=0．122）、头围Z得分（t=1．03，P=0．311）和胸围Z得分（t=-0．89．P=0．372）的比较差异无统计学意义。男婴的头围Z得分（t=2．15，P=0．034）、胸围Z得分（t=2．37，P=0．019）明显高于女婴，差异有统计学意义。结论214名乙型肝炎病毒携带孕妇分娩的新生儿发育状况较好。未发现乙型肝炎病毒宫内感染对新生儿发育有影响。

Effect of hepatitis B virus intrauterine infection on growth and development of neonates

Objective To assess the growth status of 214 neonates of hepatitis B virus(HBV) carrying pregnant women,and to study the effect of HBV intrauterine infection on the growth and development of neonates.Methods After delivery,the weight,body length,head circumference and chest circumference of the neonates were measured.Among 214 neonates,those infected with HBV by intrauterine infection were selected as intrauterine infection group,with the rest as non-infection group.Growth statuses of 214 neonates were evaluated using Z scores.Data was analyzed by SPSS and T test were applied to analyze the effect.Results Among 214 neonates,there were only three neonates with Z scores of H/A less than-2,who was diagnosized as growth retardation.There was no significant difference in Z scores of W/A(t=0.21,P=0.832),H/A(t=1.60,P=0.122),head circumference(t=1.03,P=0.311) and chest circumference(t=0.89,P=0.372) of neonates between two groups.Z scores of head circumference(t=1.03,P=0.311) and chest circumference(t=0.89,P=0.372) of the neonates in male group were significantly higher than those in female group.Conclusion The growth status of 214 neonates of HBV carrying pregnant women was quite well.The effect of HBV intrauterine infection on the growth and development of neonates had not been found.