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Skin absorption potential of ZnO nanoparticles |
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| Authors: | Sun Yae Kim Sang Hoon Jeong Eun Young Lee Yoon-Hee Park Hyun Cheol Bae Yeon Sue Jang Eun Ho Maeng Meyoung-Kon Kim Sang Wook Son |
| Affiliation: | 1. Laboratory of Cell Signaling and Nanomedicine, Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science, Korea University College of Medicine, Seoul, Korea 2. Korea Testing and Research Institute, Seoul, Korea 3. Department of Biochemistry & Molecular Biology, Korea University College of Medicine, Seoul, Korea |
| Abstract: | In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, there are insufficient data on their potential of skin absorption. This study was conducted to investigate the potential of skin absorption induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin absorption was estimated using 3D EpiDerm? model (EPI-200) as human skin equivalent model (HSEM). This study demonstrated no evidence of significant penetration of ZnO NPs into the HSEM after 24 h exposure. |
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