祛风清热化瘀通络汤治疗类风湿关节炎60例疗效观察

目的观察祛风清热化瘀通络汤治疗类风湿关节炎(RA)的临床疗效。方法120例类风湿关节炎患者随机分为2组,治疗组60例应用祛风清热化瘀通络汤,随症加减,水煎服,每日1剂。对照组60例应用芬必得胶囊,每次0.3 g,每日2次口服;雷公藤多甙片,每次2片,每日3次口服。观察2组疗效、症状和体征及实验室检查指标。结果治疗组总有效率91.67%,对照组总有效率86.67%,2组比较无显著性差异(P>0.05);治疗组治疗后关节疼痛、肿胀、压痛、晨僵均有改善(P<0.05),而对照组只能改善关节疼痛、肿胀和压痛(P<0.05),而不能改善晨僵(P>0.05);2组治疗后红细胞沉降率(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)、免疫球蛋白(Ig)与治疗前比较均降低(P<0.05),且降低ESR、CRP、IgG方面优于对照组(P<0.05);毒性和不良反应明显少于对照组。结论祛风清热化瘀通络汤治疗RA疗效确切。

Observation of Qufengqingro Huayutongluo Decoction on the treatment of rheumatoid arthritis

Objective To observe the effect of Decoction with expelling wind and removing heat on the treatment of rheumatoid arthritis.Methods 120 Patients with rheumatoid arthritis were randomly divided into two groups.Patients in control groups(n=60) were treated by routine therapy(buprofen,300mg,twice a day,Glucosidorum Tripterygll Totorum,2 tablets,three times a day).Patients in treatment groups(n=60) were treated by Qufengqingro Huayutongluo Decoction.Changes of sings,symptoms and Lab index were observed in both groups.Result The total effective rate in treatment group(91.67%) was not higher than that in control group(86.67%,P>0.05).There was improvement of arthralgia,engorgemen,tenderness,and morning stiffness after treatment in treatment group(P<0.05).There was not improvement of morning stiffness after treatment in control group(P>0.05).But there were improvements of arthralgia,engorgemen,and tenderness after treatment in control group(P<0.05).ESR,RF,CRP and IgG after treatment were decreased than those before treatment in both groups(P<0.05).The results showed that decrease of ESR,RF,CRP in treatment group were superior to those in control group(P<0.05).Conclusion Qufengqingro Huayutongluo Decoction has a good effect on treating rheumatoid arthritis.