Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations |
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| Authors: | Sun Heather K Ong Christine T Umer Ambreen Harper Dawn Troy Steven Nightingale Charles H Nicolau David P |
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| Affiliation: | Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA. |
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| Abstract: | The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with a mean penetration rate of 74%. |
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