鼻渊舒口服液治疗鼻窦炎的Meta分析

目的：探讨鼻渊舒口服液治疗鼻窦炎的疗效和安全性。方法：按照Cochrane系统评价的要求全面检索了中国数字医院图书馆（www．chkd．cnki．net）、中国医学科学院的中国生物医学文献光盘数据库（CBMdisk），对符合纳入标准的10篇文献共计3118名患者进行了Meta分析。结果：发表性偏倚分析显示9篇文献的倒漏斗图是对称的，可以做系统评价。对纳入的各独立研究异质性检验，X2=8．10，P=0．52，12=0％，表明10个关于鼻渊舒口服液治疗鼻窦炎的研究具有临床及统计学上的同质性，可用固定效应模型进行分析。结果9篇文献的OR=6．82，95％CI为5．38，8．65]，整体效果检验Z=15．85，P〈0．00001，鼻渊舒口服液与对照药物比较。疗效的差异有统计学意义，在森林图中，OR的95％CI横线落在无效竖线右侧，可认为鼻渊舒口服液治疗鼻窦炎有效。结论：从现有的临床证据来看，鼻渊舒口服液治疗鼻窦炎有效，安全性较高，值得推广应用。

A Meta Analysis of Nasosinusitis Relieving Oral Liquid for Sinusitis

Objective： To assess the efficacy and safety of nasosinusitis relieving oral liquid for sinusitis. Methods： According to Cochrane systematic review demand global search： www.chkd.cnki.net, CBMdisk. Results： Nine randomized controlled trial, including 3118 patients, met the fit into criteria. Publication bias analysis display the funnel plot is symmetric. Test for heterogeneity the fit into studies have clinical homogeneity and statistical homogeneity （ X 2 = 8.10, P=0.52, I2 =0%）, use fixed effect model analysis, incorporation analysis display the nasosinusitis relieving oral liquid versus control medicine the odds ratio is 6.82, 95%CI in 5.38, 8.65], test for overall effect Z=15.85, P 〈 0.00001, nasosinusitis relieving oral liquid and control medicine comparison the divergence of curative effect possess the high statistical significance. In forest plot the 95%CI horizontal line of incorporation odds ratio drops to being living the invalid upright string right side. May Judgement nasosinusitis relieving oral liquid treats sinusitis valid. Conclusion： Now clinical evidence display that efficacy and safety of nasosinusitis relieving oral liquid for sinusitis.