冠心病患者血清hs-CRP和E-Selectin检测的临床意义

目的:探讨了冠心病患者血清超敏C反应蛋白(hs-CRP)和E-选择素(E-Selectin)水平的变化及意义.方法:应用免疫比浊法检测hs-CRP,ELISA法检测E-Selectin水平对58例冠心病患者进行了血清hs-CRP,E-Selectin水平检测.其中稳定型心绞痛25例,不稳定型心绞痛20例,急性心肌梗死13例,并以35名正常健康人作比较.结果:冠心病患者血清hs-CRP和E-Selectin水平明显高于正常人组(P＜0.01),急性心肌梗死组和不稳定型心绞痛组有明显高于稳定型心绞痛组(P＜0.01),冠心病组血清hs-CRP、E-Selectin水平与冠状动脉狭窄程度无明显相关性(P＞0.05).结论:血清hs-CRP和E-Selectin水平的变化与冠心病的发生、发展有关,但与冠状动脉狭窄程度无关.

Clinical Significance of Determination of Serum Hypersensitive C-reactive Protein (hs-CRP) and E-Selectin Levels in Patients with Coronary Heart Diseases

Objective To investigate the significance of determination of serum contents of hs-CRP and E-Selectin in patients with coronary heart diseases (CHD). Methods Serum hs-CRP Contents were determined with immuno-turbidity and E-Selectin contents were determined with ELISA in 58 patients with CHD (35SAP, 20UAP, 13AMI) and 35controls. Results Serum levels of hs-CRP and E-Selectin in CAD patients were significantly higher than those in controls (P<0.01). Among the CHD patients, the levels of hs-CRP and E-selectin in AMI and UAP groups were significantly higher than those in SAP group(P<0.01). There was no correlationship between degree of stenosis of coronary artery and serum levels of hs-CRP and E-Selectin (P>0.05). Conclusion The serum levels of hs-CRP and E-Selectin were correlated to the development of CAD, but not to the coronary artery calibers.