Determination of antitubercular drugs in human plasma by HPLC through direct injection |
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| Authors: | C Altomare A Carotti S Cellamare G Leogrande D De Vito |
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| Institution: | Dipartimento Farmaco-Chimico, Università di Bari, Italy. |
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| Abstract: | A simple and efficient method is described for the direct determination of Isoniazide (INH) and Pyrazinamide (PZAm) in human plasma, based on reversed-phase HPLC. A number of other antitubercular drugs such as p-Aminosalycylic acid (PAS), Streptomycin (STM) and Ethambutol (ETH) and the major metabolites of the two investigated drugs, namely N-Monoacetylisoniazide (AcINH) and Pyrazinoic acid (PZAc), were shown not to interfere with the assay method. A potential application of the method to routine clinical monitoring of antitubercular drugs is discussed. |
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