大鼠深Ⅱ度烫伤后创面愈合过程中纤溶变化的意义

为探讨烧伤深Ⅱ度创面早期加深及其愈合与纤溶功能变化的关系，观察了深Ⅱ度烫伤大鼠伤后１０天内创面组织学和纤溶反应的变化。Ｍａｓｓｏｎ胶原染色显示创面在伤后７２小时内逐步加深，伤后１０天见新生结缔组织和创缘表皮增殖匍行。对血浆和创面活检组织２４小时浸出液中纤溶指标的测试表明伤后２小时创面纤溶反应激活，但在伤后２４小时已呈抑制状态，并持续至伤后１０天，纤溶指标动态变化和相关性分析提示纤溶抑制因素可能来自

The changes of fibrinolysis in plasma and wounds in rats inflicted with deep partial thickness burns]

We observed the changes in wound histopathology and fibrinolysis of rats with deep partial thickness burns during 10 days after scalding in order to study the relations of early progressive damage of deep partial thickness burn wound and the healing of the wound to fibrinolysis. Using Masson's trichrome stain of collagen, we demonstrated that partial thickness burn wound progressively deteriorated within 72 hours postburn, and epidermal cells on wound edge proliferated, creeping between necrotic and residual collagen by 10th day postburn. The results of assays of fibrinolytic parameters in plasma and 24 hour exudate from wound showed that fibrinolysis activated at 2 hour postburn but had been suppressed by 24 hour postburn till last day (10 day postburn) of the observation. The analysis of dynamic changes and relations in fibrinolytic parameters revealed that the suppressive factors of fibrinolysis might be enhanced activities of PAI, alpha 2-antiplasmin and antithrombin II after injury. Results suggested that suppression of fibrinolysis might protect fibrin deposited in the wound from lysis and play an important role in early progressive deterioration of deep partial thickness burn and regulation of its healing.