首页 | 本学科首页   官方微博 | 高级检索  
     


Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
Authors:S Obara  H Muto  H Kokubo  N Ichikawa  M Kawanabe  O Tanaka
Affiliation:Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd., Niigata, Japan.
Abstract:
Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very slight erythema was observed in both skins and this polymer was categorized as a "mild irritant". In the eye irritation test, with a dispersion of the same concentration, it was categorized as "marginal" in unrinsed eyes and "negative" in rinsed eyes.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号