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| 蒙药消肿散涂膜剂抑菌及皮肤吸收毒性实验研究 | |
| 引用本文： | 夏嫱,李文娜,但家立,王锋,张述禹. 蒙药消肿散涂膜剂抑菌及皮肤吸收毒性实验研究[J]. 遵义医学院学报, 2008, 31(1): 28-29 |
| 作者姓名： | 夏嫱 李文娜 但家立 王锋 张述禹 |
| 作者单位： | 1. 遵义医学院珠海校区免疫与病原微生物学教研室,广东,珠海,519041 2. 内蒙古医学院,药学院,内蒙古,呼和浩特,010059 |
| 摘 要： | 目的研究蒙药消肿散涂膜剂的抑菌作用及皮肤吸收毒性。方法采用体外平皿培养法和小鼠皮下注射金葡菌造模观察药物的抑菌作用，并进行皮肤吸收毒性实验测定小鼠的最大耐受量。结果消肿散涂膜剂与原剂型一样，对大肠杆菌、痢疾杆菌、白色葡萄球菌、金黄色葡萄球菌和乙型链球菌等五种标准菌株均有较强的抑菌作用，其中，对金黄色葡萄球菌和乙型链球菌的抑制作用最强。对小鼠皮肤感染模型也有保护效应（P〈0.05）。最大给药耐受量在80g/kg日以上。结论消肿散涂膜剂保留了原剂型的抗菌、低毒的特点，对体表化脓性感染性炎症可能有效。 |
| 关 键 词： | 消肿散涂膜剂 抑菌作用 吸收毒性实验 |
| 文章编号： | 1000-2715(2008)01-0028-02 |
Antibacterial effect and acute absorption toxicity of XIAOZHONGSAN paint |
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| XIA Qiang,LU Wen-na,DAN Jia-li,WANG Feng,ZHANG Shu-yu. Antibacterial effect and acute absorption toxicity of XIAOZHONGSAN paint[J]. Acta Academiae Medicine Zunyi, 2008, 31(1): 28-29 | |
| Authors: | XIA Qiang LU Wen-na DAN Jia-li WANG Feng ZHANG Shu-yu |
| Affiliation: | XIA Qiang1,LU Wen-na1,DAN Jia-li1,WANG Feng1,ZHANG Shu-yu2 (1. Zunyi Medical College,Zhuhai Campus,Zhuhai 519041,Guangdong,China,2. Department of immunology , pathogenic microorganism,Inner Mongolia Medical College,Pharmacy faculty,Huhehaote,010059,Neimenggu China) |
| Abstract: | Objective To study the antibacterial effects and acute absorption toxicity of XIAOZHONGSAN paint. Methods The antibacterial effects were measured by plating method and subcutaneous injection of Staphylococcus aureus in mouse. The acute absorption toxicity was observed by painting the drug on the skin of mouse. Results Compared with the old form, XIAOZHONGSAN paint had the same inhibitory effects on the growth of Bacterium coli, Bacterium dysenteriae, Staphylococcus albus, Staphylococcus aureus and beta stre... |
| Keywords: | XIAOZHONGSAN paint antibacterial acute absorption toxicity testing |
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