伴高同型半胱氨酸血症的缺血性脑卒中患者的危险因素研究 |
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引用本文: | 陈忠云 神经内科,北京,),高金颖 体验中心,北京,),李婧 神经内科,北京,),杨旭 神经内科,北京,),李新毅. 伴高同型半胱氨酸血症的缺血性脑卒中患者的危险因素研究[J]. 神经损伤与功能重建, 2012, 7(6): 422-424 |
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作者姓名: | 陈忠云 神经内科 北京 ) 高金颖 体验中心 北京 ) 李婧 神经内科 北京 ) 杨旭 神经内科 北京 ) 李新毅 |
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作者单位: | 陈忠云 (航天中心医院(北京大学航天临床医学院)神经内科,北京,100049); 高金颖 (航天中心医院(北京大学航天临床医学院)体验中心,北京,100049);李婧 (航天中心医院(北京大学航天临床医学院)神经内科,北京,100049); 杨旭 (航天中心医院(北京大学航天临床医学院)神经内科,北京,100049);李新毅(山西医学科学院山西大医院神经内科,太原,030032); |
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摘 要: | 目的:分析伴高同型半胱氨酸(HHcy)的缺血性卒中患者的危险因素。方法:缺血性卒中患者124例,分为HHcy组(Hcy>20μg/mL)与非HHcy组,记录及检测相关指标,进行Logistic回归分析。结果:单因素分析表明,与非HHcy组相比,HHcy组纤维蛋白原、肌酐水平升高,叶酸、维生素B12水平降低(P<0.05);多因素分析表明,纤维蛋白原、肌酐、叶酸、维生素B12是影响伴HHcy血症的缺血性卒中患者的相关因素。结论:叶酸、维生素B12缺乏及纤维蛋白原、肌酐水平升高是伴HHcy血症的缺血性卒中患者的独立危险因素。
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关 键 词: | 高同型半胱氨酸 缺血性脑卒中 |
Risk Factors of Ischemic Stroke Patients with Hyperhomocysteinemia |
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Abstract: | Objective: The purpose of this study was to investigate the risk factors of ischemic stroke patients with hyperhomocysteinemia(HHcy).Methods: A total of 124 patients with ischemic stroke were enrolled and divided into two groups according to the homocysteine levels(>20μg/mL).The traditional risk factors for ischemic stroke of all the subjects were analyzed using logistic regression analysis.Results: Univariate non-conditional logistic regression analysis showed that the levels of fibrinogen(FIB) and creatinine(Cr) were elevated and the levels of folic acid and Vitamine B12(VitB12) were decreased relative to those in the controls(P<0.05).Multivariate stepwise non-conditional logistic regression analysis showed that FIB,Cr,folic acid and VitB12 were the risk factors.Conclusion: Deficiency of folic acid,VitB12 and elevation of Cr,FIB were the independent risk factors in ischemic stroke patients with HHcy. |
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Keywords: | hyperhomocysteinemia ischemic stroke |
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