喜炎平治疗婴幼儿喘憋性肺炎的临床疗效及安全性评价

目的：探讨喜炎平注射液治疗婴幼儿喘憋性肺炎的临床疗效与安全性。方法：210例诊断为喘憋性肺炎的患儿,按入院顺序随机分为观察组和对照组,各105例,均给予化痰、止咳、平喘、镇静、吸氧等常规对症支持治疗,合并细菌感染者,给予抗生素。对照组采用利巴韦林注射液静脉滴注治疗7 d,观察组采用喜炎平注射液静脉滴注抗病毒治疗7 d。观察两组患儿体温恢复正常的时间、肺部啰音消失时间、咳喘喘憋消失时间、X线胸片吸收时间及住院时间。结果：观察组7 d治愈率达到61.9%,总有效率高达93.3%,且能明显缩短患儿的体温恢复时间、肺部啰音消失时间、咳嗽喘憋等症状消失时间、胸片吸收时间以及住院时间,效果明显优于利巴韦林,两组比较差异均有统计学意义（P〈0.05）,且未发现有明显的不良反应。结论：喜炎平对婴幼儿喘憋性肺炎具有较好的疗效,且安全性较好,值得临床推广应用。

Clinical Efficacy and Safety Evaluation of Xiyanping in Treatment for Infants with Asthmatic Pneumonia

Objective：To investigate clinical efficacy and safety of xiyanping injection in treatment for infants with asthmatic pneumonia.Method： 210 infants who were diagnosed as asthmatic pneumonia were randomly divided into observation group and control group at hospitalization,105 cases in each group.All the patients received reducing phlegm,antitussive,relieving asthma,sedation,oxygen and other conventional symptomatic and supportive treatment,and added antibiotics to the patients who were suffered bacterial infection.On the basis of the above treatment,the control group were treated with ribavirin intravenous injection for 7 days and the observation group were treated with Xiyanping injection antiviral therapy for 7 days.The time for body temperature returned to normal,pulmonary rales disappeared time,cough and wheezing disappearance time,X-ray absorption time and length of stay were compared.Result：Of the observation group patients,the cure rate reached 61.9% in seven days,the total efficiency was up to 93.3%,and the time for body temperature returned to normal,pulmonary rales disappeared time,cough and wheezing disappearance time,X-ray absorption time and length of stay were significantly shortened.It was clear that the efficacy of Xiyanping was better than that of ribavirin,the differences were statistically significant between the groups（P〈0.05）,and there was no significant adverse reactions reported.Conclusion：There is a good effect and safety for Xiyanping in treatment for infants with asthmatic pneumonia and it was worthy of clinical application.