低密度脂蛋白胆固醇对绝经前、后正常女性骨密度影响初探

目的观察血清低密度脂蛋白胆固醇对绝经前、后正常女性骨密度的影响。方法用常规酶法测定血清低密度脂蛋白胆固醇(LDL-C);用双能X线吸收法(DXA)骨密度仪测定腰椎前后位总体(L1-4)、左侧髋部总体(T-hip)、股骨大转子区(Troch)、股骨颈(FN)和Ward’s三角区骨密度(BMD)。结果低密度脂蛋白胆固醇与绝经前女性骨密度无关,与绝经后女性大转子区和髋部总体BMD无关,校正年龄和BMI后LDL-C与绝经前女性BMD无关,与绝经后女性髋部总体骨密度正相关。结论低密度脂蛋白胆固醇对绝经前女性骨密度无影响,对绝经后女性髋部总体骨密度可能有正性影响。

Effects of Serum Low - density Lipoprotein Cholesterol on Bone Mineral Density in Pre- and post - menopausal Women

Objective To investigate the effects of serum low-density lipoprotein cholesterol(LDL-C) on bone mineral density(BMD)in pre-and post-menopausal women.Methods Blood samples of 133 pre-menopausal and 330 post-menopausal women,aged 32 to 81 years,were collected.LDL-C was measured by enzyme method.The bone mass density(BMD) of anteroposterior spine(AP,L1-4),femoral neck(FN),trochanter,total hip and Ward's triangle region was measured by DXA respectively.Correlations between serum LDL-C and BMD were analyzed accordingly.Results Serum LDL-C showed no correlation with BMD at all sites in pre-menopausal women,while positive correlation with BMD at trochanter and total hip in post-menopausal women was presented.While after adjustment for age and body mass index(BMI),there only existed positive correlation between LDL-C and BMD at total hip in post-menopausal women.Conclusions LDL-C has no effect on BMD in pre-menopausal women,while it perhaps has positive effect on BMD at total hip in post-menopausal women.