| 外源性血管内皮生长因子对损伤脊髓的作用 |
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| 引用本文： | 关永林,李盛华,李晨旭,杨永清,郑祖根.外源性血管内皮生长因子对损伤脊髓的作用[J].兰州医学院学报,2011,37(3):15-19. |
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| 作者姓名： | 关永林 李盛华 李晨旭 杨永清 郑祖根 |
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| 作者单位： | 关永林 (甘肃省中医院骨科,甘肃兰州,730050) ； 李盛华 (甘肃省中医院骨科,甘肃兰州,730050) ； 李晨旭 (甘肃省中医院骨科,甘肃兰州,730050) ； 杨永清 (兰州大学第二医院神经内科,甘肃兰州,730030) ； 郑祖根 (苏州大学第二附属医院骨科,江苏苏州,215006) ； |
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| 摘 要： | 目的 研究外源性血管内皮生长因子(VEGF)局部应用对大鼠损伤脊髓神经组织的作用.方法采用改良Allen氏重量打击法大鼠急性脊髓损伤模型.脊髓打击性损伤后,将模型大鼠随机分组,并依组别在蛛网膜下腔分别给药.A组:生理盐水10μL,B组:Matrigel蛋白胶10 μL,C组:重组人VEGF165 0.2 μg+Matr...
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| 关 键 词： | 脊髓损伤 血管内皮生长因子 脊髓组织 |
Effect of exogenous vascular endothelial growth factor on injured spinal cord |
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| Institution: | GUAN Yong-lin, LI Sheng-hua, LI Cheng-xu, YANG Yong-qing, ZHEN Zu-gena (1. Department of Orthopaedics, Traditional Chinese Medicine Hospital of Gansu Province, Lanzhou 730050, China; 2. Department of Neurology, Second Hospital of Lanzhou University, Lanzhou 730030, China; 3. Department of Orthopaedics, Second Hospital Affiliated to Suzhou University, Suzhou 215006, Jiangsu, China) |
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| Abstract: | Objective To investigate the protective effect of exogenous vascular endothelial growth factor （VEGF） on spinal cord tissue after spinal cord injury （SCI） in adult rats. Methods A contusion injury was produced to adult rats by using the modulated Allen＇s weight drop method. After SCI, seventy-two model rats were randomly divided into three groups, and the drugs were injected into subrachnoid space at the lesion site. In group A： saline 10 μL, in group B： Matrigel 10 μL, in group C： human recombinant VEGF165＋Matrigel 10 μL. 1, 2,3, 4 weeks after surgery, animals were killed to study spinal cord pathologic histology and the number of neurons. Results VEGF-treated animals had an increased amount of spared tissue in the lesion area. The number of neurons in VEGF-treated animals was much better than that in the control groups at all time points following SCI. Conclusion The exogenous vascular endothelial growth factor can protect spinal cord tissue from damage caused by spinal cord injury. |
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| Keywords: | spinal cord injury vascular endothelial growth factor spinal cord tissue |
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