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| Ki-67在卵巢癌中的表达及其临床意义 | |
| 引用本文： | 张爱臣,赵楠,张小红,冷维春,田秀娟,顾启梅. Ki-67在卵巢癌中的表达及其临床意义[J]. 中国实验诊断学, 2009, 13(8): 1069-1071 |
| 作者姓名： | 张爱臣 赵楠 张小红 冷维春 田秀娟 顾启梅 |
| 作者单位： | 1. 吉林大学中日联谊医院,妇产科,吉林,长春,130033 2. 吉林省妇幼保健院 3. 上海公共卫生医院 4. 蛟河县医院,妇产科 |
| 基金项目： | 吉林省科技厅资助课题 |
| 摘 要： | 目的研究Ki-67在卵巢癌中的表达及其临床意义。方法应用免疫组织化学法（SP方法）,检测15例正常卵巢组织,15例卵巢良性肿瘤组织及60例卵巢癌组织中Ki-67的表达情况。结果Ki-67在正常卵巢组织中为阴性表达;Ki-67在良性卵巢肿瘤组织中的阳性表达率为33.3%,在卵巢癌组织中的阳性表达率为75.0%;卵巢癌临床分期越晚、组织学分化越差,Ki-67阳性表达率越高,阳性表达率与临床分期及组织学分级有关,与病理类型无关。结论Ki-67在卵巢癌的发生、发展过程中起着重要的作用。 |
| 关 键 词： | 卵巢癌 Ki-67 免疫组织化学 |
Expression and clinical significance of Ki-67 in ovarian cancer |
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| Affiliation: | ZHANG Ai-chen, ZHAO Nan, ZHANG Xiao-hong , et al. ( China- Japan Union Hospital, Jilin University, Changchun 130033, China) |
| Abstract: | Objective To study the Expression and clinical significance of Ki-67 in ovarian cancer.Methods Immanohistochemistrieal SP method was used to detect the expression of Ki-67 in 15 eases of normal ovarian tissue and 15 cases of benign ovarian tumor and 60 eases ovarian cancer. Results Ki-67 was negatively expressed in normal ovarian tissues; The positive rate of Ki-67 was 33.3% in ovarian benign tumor,and was 75.0% in ovarian cancer.The more latter in clinical stage was and the more poorer in cell differentiation was, the more higher positive rate of Ki-67 was. The positive rate of Ki-67 was correlated with histodifferemtiation and clinical stages of ovarian cancer, but was uneorrelated with the pathological type. Conclusion Ki-67 played an important role in the development of ovarian cancer. |
| Keywords: | Ki-67 |
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