Strategies for cytosolic delivery of liposomal macromolecules |
| |
| Authors: | Fretz Marjan M Mastrobattista Enrico Koning Gerben A Jiskoot Wim Storm Gert |
| |
| Affiliation: | Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. M.M.Fretz@Pharm.uu.nl |
| |
| Abstract: | ![]()
Potential approaches to achieve cytosolic delivery of liposomal macromolecules are presented. These approaches include: (1) the co-encapsulation of fusogenic peptides into targeted drug-containing liposomes (2) coupling of the HIV-1-derived cell-penetrating peptide TAT to the surface of liposomes and (3) photochemical internalization, based on photochemically inducible permeabilization of endocytic vesicles. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
