| PAI-1及其基因启动子区4G/5G基因多态与多囊卵巢综合征的研究进展 |
| |
| 引用本文： | 孙林,关咏梅,傅松滨. PAI-1及其基因启动子区4G/5G基因多态与多囊卵巢综合征的研究进展[J]. 国际遗传学杂志, 2007, 30(1): 64-68. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
| |
| 作者姓名： | 孙林 关咏梅 傅松滨 |
| |
| 作者单位： | 1. 150081,哈尔滨医科大学附属第二医院妇产科
2. 150081,哈尔滨医科大学医学遗传学教研室 |
| |
| 基金项目： | 哈尔滨医科大学研究生创新基金 |
| |
| 摘 要： | 多囊卵巢综合征(PCOS)是育龄妇女最常见的生殖内分泌紊乱性疾病，具有高度遗传异质性，其致病原因迄今不明。PCOS有高度的家族聚集性，提示遗传因素在发病中起重要作用，遗传学研究表明影响这些激素代谢和调节的多种基因参与了PCOS的发生，其中PAI-1基因启动子区4G/5G基因多态性与PCOS的发生可能有着密切的关系。
|
| 关 键 词： | 多囊卵巢综合征；PAI-1；多态性；启动子区 |
| 修稿时间： | 2005-12-16 |
Advances in the Research of PAI-1 and 4G/5G Polymorphism in Promoter Region of PAI-1 Gene and Polycystic Ovary Syndrome (PCOS) |
| |
| SUN Lin,GUAN Yong-mei,FU Song-bin. Advances in the Research of PAI-1 and 4G/5G Polymorphism in Promoter Region of PAI-1 Gene and Polycystic Ovary Syndrome (PCOS)[J]. International JOurnal of Genetics, 2007, 30(1): 64-68. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
| |
| Authors: | SUN Lin GUAN Yong-mei FU Song-bin |
| |
| Affiliation: | 1. The Reproduction Center, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081;2. Department of Medical Genetics, Harbin Medical University, Harbin 150081 ,China |
| |
| Abstract: | Polycystic ovary syndrome(PCOS),one of the reproductive endocrine disorders,usually affects those women who are in the reproductive age.It has high genetic heterogeneity and familial aggregation. The etilogy of this syndrome is not well known so far.The genetic studies show that many genes.which influence the metabolism and modulation of these hormones may involve in pathogenesis of PCOS.4G/5G polymorphism in promoter region of PAI-1 gene may be closely correlated with PCOS. |
| |
| Keywords: | PCOS PAI-1 Polymorphism Promoter region |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《国际遗传学杂志》浏览原始摘要信息 |
