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Metabolic fate of caudate nucleus dopamine
Authors:P F Spano  N H Neff
Affiliation:1. Durham University Business School, Wolfson Building, Queens Campus, University Boulevard, Thornaby, Stockton on Tees, TS17 6BH, UK;2. School of Business and Management, Queen Mary University of London, Bancroft Building, Mile End Road, London, E1 4NS, UK;3. Sheffield University Management School, University of Sheffield, Conduit Road, Sheffield, S10 1FL, UK;4. Department of Business Management, Heriot-Watt University, Edinburgh, Scotland, EH14 4AS, UK;5. Global Action Plan (GAP), 9-13 Kean Street, London, WC2B 4AY, UK;1. Curt-Engelhorn-Centre Archaeometry (CEZA), D6, 3, 68159 Mannheim, Germany;2. Heidelberg University, Faculty of Chemistry and Earth Sciences, Institute of Earth Sciences, Im Neuenheimer Feld 234–236, 69120 Heidelberg, Germany;3. Römisch-Germanisches Zentralmuseum (RGZM), Leibniz Research Institute for Archaeology, Ernst-Ludwig-Platz 2, 55116 Mainz, Germany;4. National Archaeological Museum Athens, Tositsa 1, Athens, 106 82, Greece;5. National Research Council (CNR), Institute of Sciences of Cultural Heritage (ISPC), Via Biblioteca 4, I-95124 Catania, Italy;6. Austrian Academy of Sciences (AAS), Austrian Archaeological Institute, Hollandstrasse 11–13, 1020 Vienna, Austria;7. Tübingen University, Faculty of Humanities, Institute of Prehistory, Early History and Medieval Archaeology, Burgsteige 11, 72070 Tübingen, Germany;1. School of Earth, Environment and Society, McMaster University, 1280, Main St. W., Hamilton, ON, L8S 4K1, Canada;2. Department of Geography, University of Victoria, Victoria, Canada;3. Department of Archaeology, Ankara University, Ankara, Turkey;4. Department of Archaeology, Osmaniye Korkut Ata University, Osmaniye, Turkey;5. Department of Marine Geosciences, University of Haifa, Haifa, Israel;1. Present address: Department of Archaeology, School of Humanities, University of Glasgow, Molema Building, Lilybank Gardens, Hillhead, Glasgow G12 8QQ, Scotland;2. Institute of Archaeology, University College London, 31-34 Gordon Square, London WC1H 0PY, UK;3. School of Cultural Heritage, Northwest University, 710127 Xi’an, Shaanxi, China;1. Department of Earth and Environmental Sciences, Brooklyn College, Brooklyn, NY, 11210, USA;2. Earth and Environmental Sciences Program, The Graduate Center, New York, NY, 10016, USA;3. Institute for the Study of the Ancient World at New York University (ISAW), New York, NY, 10028, USA;4. Department of Near Eastern Languages and Civilizations, Harvard University, Cambridge, MA, 01238, USA;5. Near Eastern Archaeology Department, Ankara University, Ankara, Turkey;6. General Directorate of Mineral Research and Exploration, Ankara, Turkey;7. Geology Department, Juniata College, Huntingdon, PA, 16652, USA
Abstract:
The rate of formation of DM in the guinea pig caudate nucleus was estimated from the rate of conversion of radioactive tyrosine to DM and was found to be 32 nmole/g/h. The formation and elimination of HVA and Dopac from caudate was estimated from their accumulation after treatment with probenecid. Each acid was formed at a rate of about 15 nmole/g/h. A larger dose of probenecid was required to prevent the transport of Dopac from caudate than to prevent the transport of HVA.
Keywords:
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