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Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease
Authors:Falzone  Yuri Matteo  Domi   Teuta  Agosta   Federica  Pozzi   Laura  Schito   Paride  Fazio   Raffaella  Del Carro  Ubaldo  Barbieri  Alessandra  Comola  Mauro  Leocani  Letizia  Comi  Giancarlo  Carrera  Paola  Filippi  Massimo  Quattrini  Angelo  Riva  Nilo
Affiliation:1.Division of Neuroscience, Neuropathology Unit, San Raffaele Scientific Institute, via Olgettina 48, 20132, Milan, Italy
;2.Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy
;3.Vita-Salute San Raffaele University, Milan, Italy
;4.Division of Neuroscience, Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
;5.Neurology Unit, San Raffaele Scientific Institute, Milan, Italy
;6.Neurophysiology Unit, San Raffaele Scientific Institute, Milan, Italy
;7.Neurorehabilitation Unit, San Raffaele Scientific Institute, Milan, Italy
;8.Division of Genetics and Cell Biology, Unit of Genomics for Human Disease Diagnosis, San Raffaele Scientific Institute, Milan, Italy
;
Abstract:
Journal of Neurology - To investigate the prognostic role and the major determinants of serum phosphorylated neurofilament heavy -chain (pNfH) concentration across a large cohort of motor neuron...
Keywords:
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