The role of hot plate and general environmental stimuli in morphine analgesic tolerance |
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| Authors: | Michael T. Bardo Paul J. Wellman Richard A. Hughes |
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| Affiliation: | 1. Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA;2. Department of Psychology, Texas A & M University, College Station, TX 77843, USA;3. Department of Psychology, Iowa State University, Ames, IA 50011, USA |
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| Abstract: | ![]()
Rats given one injection of morphine (5 mg/kg) paired with a hot plate test displayed greater analgesic tolerance than rats given nine injections of morphine paired with a distinct room in which the hot plate apparatus was located. Hot plate stimuli, rather than general environmental stimuli, are prepotent in the acquisition of morphine analgesic tolerance assessed by the hot plate procedure. |
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| Keywords: | Morphine analgesia Morphine tolerance Hot plate Rat |
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