Änderungen der Lungenfunktion nach Timolol-, Metipranolol-, Pindolol- und Pilocarpin-haltigen Augentropfen bei Gesunden und Patienten mit leichtem Asthma bronchiale

Summary Lung function was studied double blind and randomized in 5 patients with mild asthma bronchiale and 10 normal adults before and 30, 60 and 90 minutes after one drop of 0.5% Timolol, 0.6% Metipranolol or 0.9% NaCl in each eye.In the asthmatics bronchoconstriction was seen after both -receptor blocking agents, more pronounced after Timolol than after Metripranolol. There was a decrease in the forced expiratory volume in one second (FEV_1.0) of 32, respectively 18%. No changes were observed in the normal subjects.In a separate studie no significant changes were seen in the mean values of 10 other asthmatic subjects after 1% Pindolol, 3% Pilocarpin or 0.9% NaCl.However, in two patients FEV_1.0 was reduced by 15% and 20% of the control values after applying Pindolol.In summary, not only -receptorblocking agents without ISA produce a bronchoconstriction in asthmatic subjects, but also -blocker with ISA in individual cases.

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Abkürzungen FEV_1.0 Ein-Sekunden-Wert - ISA intrinsische sympathikotone Aktivität - MEV maximaler exspiratorischer Fluß - Rt_os oszillatorische Resistance Ein Teil der Daten wurde der Dissertationsschrift von Frau Janette Gehre entnommen.