|
|||||
|
|
| 葡萄籽提取物的体外抗脂质过氧化作用 | |
| 引用本文： | 郭英,蔡秀成,陈秋丽,李伟. 葡萄籽提取物的体外抗脂质过氧化作用[J]. 卫生研究, 2002, 31(1): 28-30 |
| 作者姓名： | 郭英 蔡秀成 陈秋丽 李伟 |
| 作者单位： | 1. 吉林大学公共卫生学院,长春,130021 2. 吉林省卫生防疫站食品卫生监督科 3. 第一军医大学珠江医院营养科 |
| 基金项目： | 吉林省卫生厅科学基金项目 |
| 摘 要： | 以大鼠肝、脑组织匀浆为材料研究葡萄籽提取物 (GSE)的抗氧化作用。组织匀浆与GSE共浴后 ,比色法测定丙二醛 (MDA)生成量。组织匀浆与GSE共浴后 ,分别以自由基诱导剂CCl4、H2 O2 和铁离子 -抗坏血酸 (Fe2 + VC)激发脂质过氧化作用 ,以MDA产生和还原型谷胱甘肽 (GSH)耗竭作为脂质过氧化作用程度指标。结果表明 ,GSE可明显降低大鼠肝、脑组织自发性MDA的生成 ,减轻CCl4、H2 O2 、Fe2 + VC所致的肝脏脂质过氧化反应 ,减轻肝组织GSH耗竭。提示GSE具有良好的抗脂质过氧化作用。 |
| 关 键 词： | 葡萄籽提取物 脂质过氧化 丙二醛 还原型谷胱甘肽 自由基 |
| 文章编号： | 1000-8020(2002)01-0028-02 |
| 修稿时间： | 2001-02-17 |
Anti-lipoperoxidation of grape seed extracts in vitro |
|
| Guo Ying,Cai Xiucheng,Chen Qiuli,Li WeiSchool of Public,Jilin University,Changchun ,China. Anti-lipoperoxidation of grape seed extracts in vitro[J]. Journal of hygiene research, 2002, 31(1): 28-30 | |
| Authors: | Guo Ying Cai Xiucheng Chen Qiuli Li WeiSchool of Public Jilin University Changchun China |
| Affiliation: | School of Public, Jilin University, Changchun 130021, China. |
| Abstract: | The anti-lipoperoxidation of grape seed extracts (GSE) was observed by malondialdehyde (MDA) generated in liver and brain homogenates spontaneously or induced by CCl 4, H 2O 2, Fe 2+ -ascorbic acid. The exhaustion of glutathione (GSH) in liver homogenate initiated by Fe 2+ -ascorbic acid was also tested. Results showed that GSE significantly inhibited the generation of MDA in rat liver and brain homogenates both spontaneously formed or induced by CCl 4, H 2O 2 and Fe 2+ -ascorbic acid with dose-effect relationships. GSE could also reduce the exhaustion of GSH levels in mice liver. The study indicated that GSE is effective on the inhibition of lipid peroxide and on the protection of liver from injury caused by lipid peroxidation. |
| Keywords: | grape seed extract lipid peroxidation malondialdehyde glutathione free radical |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |