COMBINED RESPIRATORY EFFECTS OF COLD AIR WITH SO2 OR NO2 IN REPEATED 10-MINUTE EXPOSURES OF HYPERVENTILATING GUINEA PIGS |
| |
| Authors: | Arja I. Hälinen Raimo O. Salonen Arto S. Pennanen Veli-Matti Kosma |
| |
| Affiliation: | Department of Pathology and Forensic Medicine, University of Kuopio, Finland |
| |
| Abstract: | ![]()
Previous studies in asthmatic subjects and guinea pigs have demonstrated attenuation of bronchoconstriction in repeated exposures to clean cold dry air. In the present animal study, we have simulated short-lasting human exposures to subfreezing urban air containing sulfur dioxide (SO2) and nitrogen dioxide (NO2). The anesthetized, paralyzed, and mechanically ventilated guinea pigs had 4 consecutive 10-min exposures either to clean cold dry air or to cold air with graded concentrations of SO2 (0-5 ppm) or NO2 (0-4 ppm). Peak expiratory flow (PEF) and tidal volume (VT |
| |
| Keywords: | |
|
|
