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| 一种大鼠动脉粥样硬化斑块模型的建立 | |
| 引用本文： | 杨军珂,郭延松,吴宗贵,黑淑敏,宋云凌,胡桃红. 一种大鼠动脉粥样硬化斑块模型的建立[J]. 中国心血管杂志, 2004, 9(5): 353-356 |
| 作者姓名： | 杨军珂 郭延松 吴宗贵 黑淑敏 宋云凌 胡桃红 |
| 作者单位： | 1. 中国人民解放军第二炮兵总医院心血管内科,北京,100088 2. 中国人民解放军第二军医大学长征医院心血管内科,上海,200003 3. 中国人民解放军海军总医院神经外科,北京,100037 4. 中国人民解放军第二炮兵礼士路门诊部,北京,100820 |
| 摘 要： | 目的试建立一种大鼠动脉粥样硬化斑块模型。方法给予大鼠一次维生素D33×105U/kg体重肌肉注射、球囊损伤主动脉内皮和饲以含2％胆固醇、0.5％胆酸钠、0.2％丙硫氧嘧啶、3％猪油和维生素D31.25×106U/kg的高脂饲料90 d。结果90 d后大鼠血脂明显增高,胸主动脉形成明显的动脉粥样硬化斑块,斑块内有大量的泡沫细胞、脂质、巨噬细胞及钙化,中膜平滑肌明显萎缩;而仅饲以高脂饲料的大鼠胸主动脉结构未见改变。结论血管钙超载、内皮损伤和高脂可使大鼠主动脉形成较典型的动脉粥样硬化斑块。 |
| 关 键 词： | 动脉粥样硬化 斑块 模型 |
| 文章编号： | 1007-5410(2004)05-0353-04 |
| 修稿时间： | 2003-12-29 |
Development of a model of atherosclerosis plaque in rat |
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| YANG Jun-ke,GUO Yan-song,WU Zong-gui,HEIShu-min,SONG Yun-ling,HU Tao-hong. Development of a model of atherosclerosis plaque in rat[J]. Chinese Journal of Cardiovascular Medicine, 2004, 9(5): 353-356 | |
| Authors: | YANG Jun-ke GUO Yan-song WU Zong-gui HEIShu-min SONG Yun-ling HU Tao-hong |
| Affiliation: | YANG Jun-ke,GUO Yan-song,WU Zong-gui,HEIShu-min,SONG Yun-ling,HU Tao-hong. Department of Cardiovasology,Second Artillery General Hospital,Beijing 100088. China, Department of Cardiovasology,Changzheng Hospital,Second Military Medical U-niversity,Shanghai 200003,China, Department of Neurosurgery,Navy General Hospital,Beijing 100037,China, Second Artillery Lishi Road Clinic,Beijing 100820,China |
| Abstract: | Objective To develop a model of atherosclerosis plaque in rat. Methods Rats were treated with one intramuscular injection of vitamin D3(3×105U /kg) and were denudated of endothelium, followed by high-cholesterol diet for 90 days. Results After 90 days, serum total cholesterol, triglyceride, LDL-C of the rats were higher compared with the normal rats. Distinct atherosclerosis plaques were formed in the thoracic aortas. There were amounts of foam cells , lipids, macrophages in the plaques, calcification and smooth muscle atrophy in middle membrane were also seen. The aorta structure of rats fed with only high-cholesterol diet (no vitamin D3) were normal. Conclusion Vascular calcium overload, endothelium denudation, and high-cholesterol diet can form a distinct atherosclerosis plaque in rat. |
| Keywords: | Atherosclerosis Plaque Model |
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