吉非罗齐的合成

目的：合成吉非罗齐，并进行工艺改进。方法以２，５－二甲基苯酚为起始原料，与１－氯－３－溴丙烷反应，得３－（２，５－二甲基苯氧基）－１－氯丙烷，再与异丁酸钠锂作用，制得吉非罗齐。结果：通过两步反应制得产物，总收率４３．８％，醚化反应经优化后收率较文献提高３０％以上。合成产物经红外光谱，核磁共振谱及质谱确证。结论：缩短了反应步骤，提高了反应收率。

Synthesis of gemfibrozil

OBJECTIVE:To synthesize gemfibrozil and optimize the process.METHOD:Gemfibrozil was synthesized from 3 (2,5 xylyloxyl) propyl chloride which was reacted with sodium isobutyrate first and then react with n butyllithium.3 (2,5 xylyloxyl) propyl chloride was prepared from 2,5 dimethylphenol reacting with 1 bromo 3 chloropropane.RESULTS:Gemfibrozil was synthesized in two steps with the overall yield of 43.8%.The yield of etherification increased by 30% or more as compared with that in literature.The chemical structure of synthetic product were confirmed by IR, 1HNMR,MS.CONCLUSION:The synthetic route was simplized and the overall yield was raised.