乳腺纤维腺瘤中医辨证分型与激素受体表达相关性研究

目的：研究乳腺纤维腺瘤（FA）患者中医辨证分型与雌激素受体（ER）、孕激素受体（PR）表达的相关性。方法：收集156例FA患者的临床资料,按中医辨证分型分为：肝郁气滞型76例、痰瘀互结型80例,并采用免疫组织化学染色SP法对患者术后的FA标本进行ER、PR表达的检测,对其间的相关性进行对比分析。结果：FA中肝郁气滞型与痰凝血瘀型在发病年龄、肿瘤大小、肿瘤再发率及月经情况比较差异有统计学意义（P〈0.05）;两分型在病程、肿瘤单发、多发、伴发乳腺增生病、月经初潮年龄、人流、哺乳情况及ER、PR表达的强度及阳性率比较差异无统计学意义（P〉0.05）。结论：ER、PR高表达在FA的发生、发展中起重要的激活作用,可作为对FA进行内分泌治疗的依据,但不能作为FA中医辨证分型的依据;由于痰凝血瘀型FA的发病年龄小、肿瘤大、再发率较高,药物干预性治疗的疗程应适当延长。

Research on Relationship between TCM Syndrome of Breast Fibroadenoma and Expression of Hormone Receptor

Objective：To study the relationship between TCM Syndrome of breast Fibroadenoma and expression of estrogen receptor（ER） and progesterone receptor（PR）.Methods： According to the TCM syndrome,156 cases of FA patients were divided into 2 types：76 cases of liver qi stagnation type,80 cases of congealation of phlegm and blood stasis type.Using method of SP immunohistochemistry to detect the expression of ER and PR in FA specimens after operation,analysis the relationgship between two groups.Results： There were statistical difference in age,tumor size,tumor recidivism rate,menstruation between two groups（P〈0.05）;but there were no significant difference in course of disease,numbers of tumor,hyperplasia of mammary glands,age of menarche,induced abortion,breast-feeding situation and positive rates and expression strength of ER and PR between two groups（P〈0.05）.Conclusion： It is very important of the high expression of ER and PR in occurrence and development of FA.It could be used as reference for endocrine therapy,but couldn＇t be applied as basis for the syndrome differentiation of FA.Becaue the age of patients is younger,the tumor is bigger,and the recidivism rate in congealation of phlegm and blood stasis type group is much higher than that of liver qi stagnation type,the time of treatment should to be extended appropriately.