骨骼系统PET/CT显像和核医学平面显像对比研究

目的:探讨单光子发射计算机断层(SPECT)骨显像和PET/CT骨显像结果的差异及可能的原因。方法:对2例病例均先后行SPECT骨显像和PET/CT骨显像,并对图像进行对比分析。结果:骨骼对18F-fluoride(PET/CT骨显像剂)和99mTc-MDP(SPECT骨显像剂)的摄取机理类似,均可以反映局部血流量及骨代谢更新的活跃程度,由于18F-fluoride与骨的亲和力强于99mTc-MDP,因此PET/CT图像具有比SPECT更高的系统分辨率和系统灵敏度。结论:PET/CT骨显像灵敏度和分辨率均高于SPECT,但由于其检查费用较高及自身受18F的短半衰期限制,因而其在临床应用受到一定的限制。

Comparative Study between PET/CT Imaging and Nuclear Medicine Plane Imaging of Bone System

Objective To compare the difference between single-photon emission computed tomography（SPECT） bone imaging and positron emission tomography/X-ray computed tomography（PET/CT） bone imaging and find the possible reasons.Methods The two patients underwent SPECT imaging and PET/CT whole-body scan,and the diagnostic sensitivity,accuracy and so forth were compared.Results The bone uptake mechanism of 18F-fluoride（PET/CT bone imaging agent） was similar to that of 99mTc-MDP（SPEC bone imaging agent）,both of which could reflect local blood flow and activity level of bone metabolism.18F-fluoride had higher congeniality with bone compared with 99mTc-MDP,so the resolution and sensitivity of PET/CT image were significantly higher than those of SPECT image.Conclusion The resolution and sensitivity of PET/CT image are significantly higher than those of SPECT image,but its application in clinical is quite limited due to its high expense and short half life of 18F.[Chinese Medical Equipment Journal,2012,33（6）：70-71]