表皮生长因子受体在鼻咽癌组织中的表达及意义

目的 探讨表皮生长因子受体（EGFR）在鼻咽癌（NPC）组织中的表达及临床意义.方法 应用免疫组织化学SP法检测55例NPC组织及20例鼻咽非肿瘤组织EGFR表达.结果 鼻咽癌组织EGFR阳性率96,3%（53/55）明显高于正常鼻咽黏膜组织中和10%（2/20）（x2=7.123,P＜0.01）;鼻咽癌组织中EG-FR蛋白的过表达率与淋巴结转移、远处转移有相关性（x2=3.785、3.845,P＜0.05）;5年总生存率（overall survival,OS）为65.5%,低表达患者5年总生存率75.35%,明显高于高表达52.4%（x2=3.925,P＜0.05）;用Cox比例风险模型分析显示T分期、N分期和年龄是OS的独立预后因素（P=0.001,P=0.009,P=0.019）.结论 EGFR与鼻咽癌的发生、发展有关可作为评估鼻咽癌进展和判断预后的重要指标.

Expression and Clinical Significance of EGF Receptor in Nasopharyngeal Carcinoma

Objective To investigate the expressions and clinical significance of epidermal growth factor receptor(EGFR) in patients with nasopharyngeal carcinoma(NPC). Methods 55 cases with NPC and 20 cases with noncancerous nasopharyngeal epithelial samples were retrospectively studied and the expressions of EGF and IGF-1 receptors were detected by immunohistochemical staining. Results The positive rate of EGFR 96.3% (53/55) in nasopharyngeal carcinoma was significantly higher than the 10% ( 2/20 ) in normal nasopharyngeal mucosa ( x2 =7. 123,P ＜ 0. 01 ) ;EGFR protein over-expression in nasopharyngeal carcinoma with lymph node metastasis, distant metastasis were correlated ( x2 = 3. 785, x2 = 3. 845, P ＜ 0. 05 ); The 5 -year overall survival ( OS ) in NPC was 65. 5 %,The patients with low expression of 5-year overall survival 75.35% was significantly higher than the 52.4% in high expression( x2 = 3. 925,P ＜ 0. 05 ); Using Cox proportional hazards model analysis showed that T stage, N stage and age are OS independent prognostic factor(P =0.001 ,P=0. 009,P =0.019). Conclusion EGFR had synergistic effects and may play an important role in the development and progression of NPC. The expression of EGFR could be useful biomarkes to assess clinical status and prognosis of patients with NPC.