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| 缺血性脑损伤后多巴胺和5羟色胺含量的变化 | |
| 引用本文： | 柏蕙英,余孟钟,叶铮. 缺血性脑损伤后多巴胺和5羟色胺含量的变化[J]. 上海交通大学学报(医学版), 1987, 0(2) |
| 作者姓名： | 柏蕙英 余孟钟 叶铮 |
| 作者单位： | 上海第二医科大学基础部解剖教研室(柏蕙英)，美国新泽西州州立医科大学神经科学实验室(余孟钟)，昆明医学院解剖教研室(叶铮) |
| 基金项目： | Kimber-Mccurdy Foundation基金 |
| 摘 要： | 对沙土鼠(gerbil)进行单侧颈总动脉结扎,做成单侧脑缺血的动物模型,运用高效液相色谱电化学检测仪测定,研究额叶皮质区、尾状核区、海马区内神经递质多巴胺及5羟色胺在恢复过程中不同存活期内的含量变化,其中下降最显著的在海马组内,损伤侧DA下降到仅占对照侧的33%,P<0.01(第七天);在尾状核组内,5HT下降到仅占对照侧的38%,P<0.01(第七天),但额叶皮质组内二者变化不显著,为防治脑血管疾患提供了客观指标。 |
| 关 键 词： | 脑缺血性损伤 多巴胺 5羟色胺 |
Effect of Cerebral Ischemia on Neurotransmitters in Various Regions of Brain |
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| Bai Huiying,et al. Effect of Cerebral Ischemia on Neurotransmitters in Various Regions of Brain[J]. Journal of Shanghai Jiaotong University:Medical Science, 1987, 0(2) | |
| Authors: | Bai Huiying et al |
| Affiliation: | Bai Huiying,et al Department of Anatomy,Shanghai Second Medical University,Shanghai. |
| Abstract: | The effect of cerebral ischemia caused by transient unilateral carotid artery ligation on the level of neurotransmitters, such as Dopamine (DA) and Serotonin (5-HT) in three regions of brain (i.e. frontal cortex, caudate and hippocampus) in gerbil was studied.Using highly sensitive LCEC the levels between the operated side and normal non-operated side during Various recovery periods were compared. The lowest level of DA was found in hippocampus,being 33% of the control side(P<0.01) and the lowest level of 5-HT was observed in caudate, being 38% of the control side (P<0.01). However, the contents of both DA and 5-HT showed no obvious change in the frontal cortex. The significance of these results was discussed. |
| Keywords: | cerebral ischemia dopamin serotonin |
| 本文献已被 CNKI 等数据库收录！ | |