以EGFR为靶点的肿瘤分子靶向药物研究进展

随着分子生物学的发展，肿瘤靶向药物逐渐成为肿瘤治疗的研究热点，越来越多的靶向药物进入临床。肿瘤靶向药物主要分为单克隆抗体以及单或多靶点小分子抑制剂两大类。综述肺癌、乳腺癌及结直肠癌等常见肿瘤中各类靶向药物的分类及其特点，以探讨抗肿瘤药物的研究进展，并比较中国和美国靶向药物的批准情况和适应证差异。

Comparing antibody and small-molecule therapies for cancer

With the progress of molecular biology, targeted tumor therapy has become a hot research topic in cancer treatment, with increased number of targeted drugs entering clinical trials. According to their nature, targeted drugs can be mainly grouped into two categories: monoclonal antibody and single targeted or multi-targeted small molecule inhibitors. This article summarizes the classification and characteristics of various targeted drugs for common tumors such as lung cancer, breast cancer and colorectal cancer, explores the research progresses of anti-tumor drugs and compares the approval status and indications of targeted drugs between China and the United States.