| 马莲鞍的化学成分研究 |
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| 引用本文： | 朱晓雨, 白一丹, 李思谦, 柳文媛. 藤苦参强心苷抗肿瘤作用研究进展[J]. 药学进展, 2018, 42(6): 459-465. |
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| 作者姓名： | 朱晓雨 白一丹 李思谦 柳文媛 |
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| 作者单位： | 1.中国药科大学药物质量与安全预警教育部重点实验室，江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目（No.81573557） |
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| 摘 要： | 
藤苦参为萝藦科植物，其主要成分为强心苷类化合物。藤苦参的抗肿瘤作用近年来逐渐受到关注。综述藤苦参中分离出的强心苷的化学结构、抗肿瘤活性、构效关系及作用机制等方面的研究进展，以期为藤苦参抗肿瘤药效成分的深入研究提供参考。
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| 关 键 词： | 藤苦参 强心苷 抗肿瘤活性 作用机制 |
Cardiac glycosides and breast cancer |
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| ZHU Xiaoyu, BAI Yidan, LI Siqian, LIU Wenyuan. Research Progress in Antitumor Effects of Cardiac Glycosides from Streptocaulon griffithii[J]. Progress in Pharmaceutical Sciences, 2018, 42(6): 459-465. |
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| Authors: | ZHU Xiaoyu BAI Yidan LI Siqian LIU Wenyuan |
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| Affiliation: | 1.Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China |
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| Abstract: |
Streptocaulon griffithii belongs to family Asclepiadaceae, and its major constituents are cardiac glycosides. Streptocaulon griffithii has attracted great attention for its antitumor effect in recent years. This review summarized the research progress in the chemical structures, antitumor effects, structure-activity relationship and mechanisms of action of cardiac glycosides from Streptocaulon griffithii, so as to provide reference for further investigation on the bioactive components with anti-tumor potential in Streptocaulon griffithii.
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| Keywords: | Streptocaulon griffithii cardiac glycoside antitumor effect mechanism of action |
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