梅毒对HIV-1感染者病毒载量和CD4+T细胞计数的影响

目的:评估梅毒对HIV-1感染者血浆HIV-1病毒载量,CD4 T细胞计数的影响.方法:于1年前对HIV-1感染者进行梅毒ELISA和RPR检测,对RPR检测阳性者根据其CD4 T细胞计数和病毒载量进行配对,与1年后重新检测CD4 T细胞计数与病毒载量比较,用配对资料的t检验分析梅毒对HIV感染者CD4 T细胞与病毒载量的影响.结果:在271例HIV-1感染者中,共11例梅毒阳性者,占4.1%.本研究中包括HIV-1感染者20例,其中10例梅毒与HIV-1共感染者.在梅毒与HIV共感染者病例中,CD4 T细胞计数明显降低(99个细胞/ml),但病毒载量的变化没有显著差异.结论:梅毒显著地降低HIV-1感染者的CD4 T细胞数量,但病毒载量没有明显的变化.为了延缓HIV-1感染者进入AIDS阶段的时间,应加强对梅毒的治疗和采取相应的预防措施.

Effect of syphilis on HIV viral load and CD4 +T cell count in patients with HIV-1

Objective: To assess the effect of syphilis on HIV viral load(VL) and CD4 T cell count in HIV-1 infected individuals.Methods: The coinfection of syphilis and HIV-1 was diagnosed by ELISA and RPR test a year ago.At the same time,CD4 T cell count and HIV viral load were detected.According to CD4 T count and HIV viral load of infectors with syphilis,the people who only were infected with HIV-1 were selected.A year later,HIV-1 load and CD4 T count were detected again,and the effect of syphilis on CD4 T count and HIV-1 viral load of population with HIV-1 were analyzed with SAS software. Results: Of 271people with HIV-1,11(4.1%) were syphilis test positive.In this case-control study,there was 20 people with HIV-1 including 10 peoples with syphilis and HIV-1.In coinfection group,CD4 T count decreased more significantly than another group.But HIV loaded in serum had no difference between two groups. Conclusion: Syphilis infection was associated with a decrease in the CD4 T cell count,and no obvious difference in the HIV VL.In order to delay the time from HIV-1 latent phase to AIDS,the measure to treat and prevent syphilis should be strengthened.