冠心病患者血浆超敏C反应蛋白、血小板聚集率和D-二聚体水平测定及相关性分析

目的研究冠心病患者血浆超敏C反应蛋白(hs-CRP)、血小板聚集率和D-二聚体(D-D)水平及其临床相关性。方法选不同类型冠心病患者128例(冠心病组)和健康体检者40例(对照组),分别采用免疫比浊法和自身红细胞凝集法检测血浆hs-CRP、血小板聚集率和D-D水平,并进行相关性分析。结果冠心病组血浆hs-CRP、血小板聚集率、D-D水平明显高于对照组(P<0.01),且急性冠脉综合征(ACS)[急性心肌梗死(AMI)>不稳定型心绞痛(UA)]>稳定型心绞痛(SAP)>隐匿性冠心病,差异有显著性(P均<0.01)。hs-CRP、血小板聚集率和D-D三者有直线相关关系。结论 hs-CRP、血小板聚集率和D-D与冠心病发生、发展密切相关,联合检测有利于冠心病的早期诊断、临床分型、病情判断及指导临床用药。

The detection of hypersensitivity C-reactive protein, platelet aggregation, D-dimer and their correlation analysis in patients with coronary heart disease

Objective To study tbe levels of hypersensitivity C-reactive protein(hs-CRP),maximal platelet aggregation(MPA),D-dimer(D-D) and to assess their clinical correlations in patients with coronary heart disease(CHD).Methods 128 patients with different types of coronary heart diseases (a CHD group) and 40 healthy subjects undergoing physical examination(a control group) were enrolled in this study.An immunity turbidimetry and self red blood cell aggregation test were used to measure the levels of plasma hs-CRP,MPA and D-D and the correlation analysis was also done.Results In the CHD group,the levels of plasma hs-CRP,MPA and D-D elevated significantly,compared to the control group,there were statistically significant differences(P<0.01).While the above indices ranged as: acute coronary syndrome(ACS) [acute myocardial infarction(AMI)>unstable angina(UA)]>stable angina pectoris(SAP)>latent CHD,compared among these groups,there were statistically significant differences(all P<0.01).hs-CRP,MPA and D-D had linear correlation.Conclusion Plasma hs-CRP,MPA and D-D have positively associated with genesis and development of CHD,the combination detection benefits for early diagnosis,clinical typing,predicting disease and drug guidance for CHD.