胃癌中 Survivin 和 Cox-2 的表达与临床病理因素的关系

目的：探讨凋亡抑制蛋白Survivin和Cox-2在胃癌中的表达及其相关性与临床意义。方法：采用免疫组织化学sP法检测Survivin和Cox-2蛋白在60例胃癌和20例切缘正常的胃粘膜中的表达。分析Sur-vivin和Cox-2表达与胃癌临床病理因素的关系及两者的相关性。结果：胃癌组织和切缘正常的胃粘膜中，Survivin蛋白阳性率分别为68．3％和0％；Cox-2蛋白阳性率分别为80．O％和1．7％。统计学分析结果表明，Survivin和Cox-2在胃癌的表达均高于切缘正常的胃粘膜（P〈0．01）。Survivin蛋白在胃癌中表达阳性率与性别、年龄、肿瘤大小等因素无关（P〉0．05），但与肿瘤分化程度、浆膜侵犯、淋巴结转移密切相关（P〈0．05）。Cox-2蛋白在胃癌中的表达阳性率与性别、年龄、肿瘤大小、肿瘤分化程度、浆膜侵犯等因素无关（P〉0．05），但与淋巴结转移密切相关（P〈0．05）。胃癌中Survivin与Cox-2之间具有显著正相关性（P〈0．05）。结论：Survivin蛋白和Cox-2蛋白在胃癌的发生发展中起重要作用。Survivin蛋白与Cox-2蛋白表达密切相关，二者可能存在共同的激活机制，构成肿瘤细胞凋亡的多种途径。二者的检测可作为反映胃癌生物学行为和判断预后的有效指标之一。

Relaionship between the expression of Survivin,Cox-2 and the clinical pathological factars in gastric carcinoma

Objective:To investigate the expression,relationship and clinical significance of Survivin and Cox-2 in gastric carcinoma.Methods:The exprssion of Survivin and Cox-2 were studied by immunohistochemistry SP in 60 gastric carcinoma specimen and 20 normal slice-edge mucosa gastric specimen.The relationship between exprssion of Survivin,Cox-2 and clinical pathological parameter were analyzed,also the relationship between Survivin and Cox-2.Results:The positive expression rates of Survivin were 68.3% and 0% in gastric carcinoma specimen and normal tissue respectively,while Cox-2 were 80.0% and 1.7%.The statistical results showed that expressions of Survivin and Cox-2 in gastric carcinoma were higher than those in normal gastric tissues(P<0.01).The positive expression rate of Survivin was not related to gender,age,carcinoma size(P>0.05).but was closely associated with cellular differentiation,serosa infiltration,lymph node metastasis(P<0.05).The positive expression rate of Cox-2 was negatively related to gender,age,carcinoma size,cellular differentiation,serosa infiltration(P>0.05),but was associated with lymph node(P<0.05).The expression of Cox-2 was positively correlated to Survivin.Conclusion:Survivin and Cox-2 play important roles in the development and progress in gastric carcinoma.The expression of survivin and Cox-2 is positively correlated.They may have the same activating mechanism,and make up of many ways of carcinoma cellular apoptosis.The detection of Survivin and Cox-2 may act as one of efficient factors to indicate biological behavior and prognosis in gastric carcinoma.