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| 非小细胞肺癌组织ERCC1表达及其与预后的相关性分析 | |
| 引用本文： | 李琳,许崇安,田大力,智连义,高艳,刘云鹏. 非小细胞肺癌组织ERCC1表达及其与预后的相关性分析[J]. 中华肿瘤防治杂志, 2010, 17(3) |
| 作者姓名： | 李琳 许崇安 田大力 智连义 高艳 刘云鹏 |
| 作者单位： | 1. 中国医科大学第四临床学院,肿瘤内科,辽宁,沈阳,110032 2. 中国医科大学第四临床学院,胸外科,辽宁,沈阳,110032 3. 中国医科大学第四临床学院,病理科,辽宁,沈阳,110032 4. 中国医科大学第一临床学院肿瘤内科,辽宁,沈阳,110001 |
| 基金项目： | 辽宁省自然科学基金项目(20082084) |
| 摘 要： | 目的:探讨ERCC1在非小细胞肺癌(NSCLC)组织中的表达及其预后的意义。方法:采用SP法检测129例手术切除NSCLC组织和10例癌旁正常肺组织中ERCC1表达情况,并进行预后随访。结果:在NSCLC组织中ERCC1表达阳性率为48.1%。ERCC1表达与年龄、性别、期别、病理类型均未见相关性,P均>0.05。ERCC1低、高表达者中位生存期为60、29个月,P=0.0001。分层分析发现Ⅰ期ER-CC1阳性表达的预后明显好于ER-CC1阴性表达,中位生存期分别为72和60个月,P=0.0165。而Ⅱ和ⅢA期ERCC1阴性表达较ERCC1阳性预后为好,Ⅱ期中位生存期分别为60和23个月,P=0.0000;ⅢA期中位生存期分别为46和15个月,P=0.0110。结论:NSCLC组织中存在ERCC1表达;ERCC1表达与患者的临床病理特征无明显相关性;ERCC1表达对Ⅰ期和Ⅱ～ⅢA期NSCLC术后生存具有双重效应;ERCC1表达状态是NSCLC患者独立预后因素之一。 |
| 关 键 词： | 癌 非小细胞肺 免疫组织化学 预后 |
Expression and prognostic significance of ERCC1 in non-small cell lung cancer tissues |
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| LI Lin,XU Chong-an,TIAN Da-li,ZHI Lian-yi,GAO Yan,LIU Yun-peng. Expression and prognostic significance of ERCC1 in non-small cell lung cancer tissues[J]. Chinese Journal of Cancer Prevention and Treatment, 2010, 17(3) | |
| Authors: | LI Lin XU Chong-an TIAN Da-li ZHI Lian-yi GAO Yan LIU Yun-peng |
| Affiliation: | LI+Lin1,XU+Chong-an1,TIAN+Da-li1,ZHI+Lian-yi1,GAO+Yan1,LIU+Yun-peng21.Fourth+Affiliated+Hospital+of+China+Medical+University,Shenyang+110032,P.R.China2.Department+of+Medical+Oncology,First+Affiliated+Hospital+of+China+Medical+University,Shenyang+110001,P.R.China |
| Abstract: | OBJECTIVE:To investigate the expression of ERCC1 in the patients with non-small cell lung cancer (NSCLC) and the clinical significance.METHODS:Immunohistochemical staining of ERCC1 was performed by the standard SP technique for the 129 cases of NSCLC tissues and 10 cases of normal lung tissues nearby the cancer tissues.All the cases were followed up.RESULTS:The positive rate of ERCC1 expression in NSCLC was in 48.1%.The expression of ERCC1 had no difference in different pathological classifications,clinical... |
| Keywords: | carcinoma non-small cell lung immunohistochemistry prognosis |
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