盐酸小檗碱酶触型结肠定位片的制备

目的用体外溶出度测定评价盐酸小檗碱结肠定位片制备工艺的可行性。方法将盐酸小檗碱加入适量微晶纤维素,以及果胶和瓜耳豆胶酶触骨架材料压制成骨架片芯,再包肠溶衣制成结肠定位骨架包衣片;以topsis法综合评定筛选工艺,以体外溶出度为指标,考察骨架包衣片释药特性。结果当果胶与瓜耳豆胶比例为1∶1、肠溶衣增重3.8%时,可使药物在人工肠液中5 h释药低于20%,在模拟结肠环境下6 h释放接近80%。结论体外溶出度初步表明,该包衣骨架片可基本达到结肠定位释药的预期效果。

Preparation of enzyme-controlled colon-positioning tablets of berbedne Hydrochloride

Objective To review the feasibility of the preparation technology of berberine hydrochloride colon-positioning tablets by dissolution test in vitro.Methods Microcrystalline cellulose(MCC)and enzyme-controlled matrix materials including pectin and guar gum were added into barbering hydrochloride for preparing the matrix tablet core,and then coating matrix tablets were prepared with enteric coating on the core.The screening technology was assessed by topsis synthesis,and the releasing rate of the coating matrix tablet was observed taken dissolution test in vitro as the index.Result When the proportion of pectin and guar gum was 1 to 1 and the weight of colon coating was gained by 3.8%,the release rate of coating matrix tablets was below 20% in artificial intestinal juice in 5 hours,and closed to 80% in simulative colon circumstance in 6 hours.Conclusion The dissoultion test showed that the coating matrix tablets could achieve the expected effects of colon-positioning release.